Table 5.
Univariate and multivariate logistic regression models predicting the likelihood of definite ILA
| Variables | Univariate
|
Multivariate
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| β | SE | OR | 95% CI | P-value | β | SE | OR | 95% CI | P-value | |
| Age, years | −0.018 | 0.014 | 0.982 | 0.955–1.010 | 0.208 | |||||
| Sex | ||||||||||
| Female | – | – | 1 | – | – | |||||
| Male | 0.293 | 0.216 | 1.341 | 0.877–2.049 | 0.175 | |||||
| FEV1, % of predicted | −0.003 | 0.005 | 0.997 | 0.987–1.008 | 0.621 | |||||
| BMI, kg/m2 | −0.036 | 0.025 | 0.965 | 0.919–1.013 | 0.148 | |||||
| Smoking status | ||||||||||
| Former | – | – | 1 | – | – | – | – | 1 | – | – |
| Current | 1.456 | 0.301 | 4.289 | 2.380–7.731 | <0.001 | 1.476 (1.400)a |
0.302 (0.309)a |
4.377 (4.054)a |
2.422–7.910 (2.214–7.421)a |
<0.001 (<0.001)a |
| Pack-years | 0.010 | 0.004 | 1.010 | 1.003–1.018 | 0.009 | 0.012 (0.014)a |
0.004 (0.004)a |
1.012 (1.014)a |
1.004–1.020 (1.005–1.022)a |
0.004 (0.001)a |
| Airflow obstruction | ||||||||||
| Absent | – | – | 1 | – | – | |||||
| Present | −0.226 | 0.220 | 0.798 | 0.519–1.227 | 0.303 | |||||
Notes: Hosmer and Lemeshow test shows χ2=4.971, P=0.761 and χ2=7.394, P=0.495 for multivariate and multivariate adjusted models, respectively.
a
Multivariate adjusted model for presence of airflow obstruction, age, and sex. Statistically significant P-values are indicated by bold font.
Abbreviations: ILA, interstitial lung disease; SE, standard error; OR, odds ratio; CI, confidence interval; FEV1, forced expiratory volume in 1 second; BMI, body mass index.