Table 6.
Univariate and multivariate logistic regression models predicting the likelihood of any fibrotic ILA
| Variables | Univariate
|
Multivariate
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| β | SE | OR | 95% CI | P-value | β | SE | OR | 95% CI | P-value | |
| Age, years | 0.160 | 0.028 | 1.174 | 1.111–1.240 | <0.001 | 0.159 (0.165) |
0.033 (0.031) |
1.172 (1.179) |
1.098–1.251 (1.109–1.254) |
<0.001 (<0.001) |
| Sex | ||||||||||
| Female | – | – | 1 | – | – | 1 | ||||
| Male | 2.519 | 1.022 | 12.419 | 1.675–92.094 | 0.014 | 2.110 (2.150) |
1.032 (1.032) |
8.245 (8.582) |
1.091–62.289 (1.134–64.920) |
0.041 (0.037) |
| FEV1, % of predicted | −0.008 | 0.010 | 0.992 | 0.972–1.012 | 0.437 | |||||
| BMI, kg/m2 | −0.003 | 0.049 | 0.951 | 0.905–1.098 | 0.951 | |||||
| Smoking status | ||||||||||
| Former | – | – | 1 | – | – | |||||
| Current | −0.452 | 0.407 | 0.636 | 0.287–1.413 | 0.267 | |||||
| Pack-years | 0.013 | 0.008 | 1.013 | 0.998–1.028 | 0.078 | |||||
| Airflow obstruction | ||||||||||
| Absent | – | – | 1 | – | – | – | – | 1 | – | – |
| Present | 0.923 | 0.425 | 2.517 | 1.095–5.787 | 0.030 | 0.009 | 0.482 | 1.009 | 0.393–2.594 | 0.985 |
Notes: Hosmer and Lemeshow test shows χ2=7.727, P=0.461 for multivariate model. Statistically significant P-values are indicated by bold font.
Abbreviations: ILA, interstitial lung disease; SE, standard error; OR, odds ratio; CI, confidence interval; FEV1, forced expiratory volume in 1 second; BMI, body mass index.