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The screening of the glutamine analogs. (a) The structures of glutamine and the library of glutamine analogs. (b) The illustration and the results of the cell uptake experiments. Compound 3 and 8 exhibit expected temperature-dependency and glutamine-dependency. Compound 3 was selected as the glutamine analog due to the better response. (c) The uptake of compound 3 in control, sodium-free media, and SLC1A5-knock down U87 cells.
