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. Author manuscript; available in PMC: 2017 Feb 3.
Published in final edited form as: Neuron. 2016 Jan 21;89(3):472–479. doi: 10.1016/j.neuron.2015.12.032

Figure 3. Pathway-specific striatal substrates for suppressing habitual lever pressing.

Figure 3

(A) Schematic of behavioral design for producing habitual (RIext, RRext) and goal-directed (RRshort) lever press behavior and subsequently omitting the same behavior. (B) Percent LPr omitted on each day of omission testing. (C–F) Linear regressions of dSPN event amplitude (C), iSPN event amplitude (D), dSPN spike probability (E), and log2-transformed dSPN/iSPN ratio for event latency (F) against LPr omitted in final omission test. (G–H) Heat maps of dSPN (X) and iSPN (●) event amplitudes in X–Y space of representative brain slices from habitual mice with the poorest (G) and best (H) lever press suppression in final omission test. n = 9 animals; 22–116 dSPNs and 15–83 iSPNs per animal (*p < 0.05). Data are represented as mean ± SEM for all cells imaged from an animal. See also Supplemental Figure 4.