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Scope of Vinyl Bromides in α-Alkenylation of 4-Pyridylmethyl Ethyl Ether 1aa
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Reactions conducted on 0.2 mmol scale using 1 equiv of 1a and 1.5 equiv of vinyl bromide 2. Isolated yields after chromatographic purification.
2.5 mol % Pd loading.
10 mol % Pd loading, 3 h reaction time.
0.5 h reaction time.
3 h reaction time.
