Table 2.

Subgroup analyses: pooled RR or HR and 95% confidence interval (CI) of obesity and incident dementia and sub-types in prospective cohort studies in the general adult population: fully adjusted models^‡

	Dementia		AD		VaD
	RR	95% CI	RR	95% CI	RR	95% CI
All	1.42	0.93, 2.18	1.80	1.00, 3.29*	1.73	0.47, 6.31
	(n=4)		(n=4)		(n=3)
Baseline age (y)
<60	1.74	1.34, 2.26*	3.10	2.19, 4.38*,†	5.01	2.97, 8.43*,†
60+	1.31	0.71, 2.39	1.38	0.94, 1.66*	0.90	0.49, 1.64
	(n= 1 and 3)		(n= 1 and 3)		(n= 1 and 2)
Sex
Men	1.59	1.17, 2.15*	2.32	1.37, 3.92*	4.07	1.93, 8.58*
Women	2.07	1.49, 2.88*	3.00	2.09, 4.33*	3.70)	1.99, 6.88*
	(n=3 and 1)		(n=2 and 2)		(n= 2 and 2
Follow-up time (y)
<10	1.17	0.54, 2.54	1.32	0.87, 1.99†	0.90	0.49, 1.64†
≥10	1.75	1.36, 2.25*	2.91	2.10, 4.03*	5.01	2.98, 8.43*
	(n=2 and 2)		(n=2 and 2)		(n=2 and 1)

^*P<0.05 for the null hypothesis that lnRR=0.

^†Significant test for heterogeneity (Q-test) with 1 degrees of freedom, comparing RRs between sex, baseline age and follow-up strata: P-value<0.05.

^‡Models were adjusted for socio-demographic factors in addition to some lifestyle factors, co-morbid conditions and/or genetic factors (mainly ApoE ε4 carrier status).

^§AD: Alzheimer’s Disease; VaD: Vascular Dementia; RR: Relative Risk; n: study datapoint used in fully adjusted models.