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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Microbiol Spectr. 2016 Apr;4(2):10.1128/microbiolspec.VMBF-0022-2015. doi: 10.1128/microbiolspec.VMBF-0022-2015

Figure 2.

Figure 2

Cell wall-anchored adhesins. All the cell wall-anchored adhesins contain an N-terminal signal sequence (SS) and a C-terminal portion that is cleaved by Sortase A at the LPXTG sequence. MSCRAMMs contain three IgG-like folds N1, N2, and N3, followed by specific ligand-binding domains. In the Sdr protein subfamily, a variable number of B repeats is found between the IgG-like folds and the SD repeat region. SdrC is shown, which contains two of these B repeats. Similarly, the Isd proteins contain one, two, or three NEAT motifs. IsdA is shown, which has one. In SpA, there are four or five IgG-binding domains, sometimes referred to as domains E, D, A, C, and B. There follows a region containing a variable number of tandem repeats.