Figure 3. Determination of specific amino acid substitution(s) responsible for enhanced replication in MDM.
(A) 3′ gp41 amino acid sequences of 3 SIVsm804E clones. Amino acid substitutions conserved among all 3 clones are indicated by in red. (B) Amino acid sequences of 5 SIVsmE543-3 clones with point mutation(s) introduced in the 3′ gp41 cytoplasmic tail. Amino acid substitution(s) are indicated in red. Asterisks indicate stop codons.