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. 2016 Apr 25;126(6):2109–2122. doi: 10.1172/JCI84978

Figure 3. Innate IFN-γ depends on RD1 and ESAT-6–mediated cytosolic contact.

Figure 3

(A–F) Percentage of IFN-γ+ cells among total viable CD3–NK1.1+ (A–C) and CD3+CD8+ (D–F) lung cells and serum IL-18 concentrations (G–I) 24 hours after B6 mice were injected with different purified mycobacterial ligands (A, D, and G) or 1 × 108 CFU WT or recombinant Mtb or BCG strains (B, C, E, F, H, and I). Individual data points of 3 to 15 mice per group from at least 2 pooled, independent experiments are shown. *P < 0.05, **P < 0.01, and ***P < 0.001, by 1-way ANOVA. rESAT-6, recombinant ESAT-6.