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. 2016 Apr 25;126(6):2109–2122. doi: 10.1172/JCI84978

Figure 7. Early control of Mtb infection by noncognate memory CD8+ T cells depends on IL-18.

Figure 7

Rag2–/–Il2rg–/– mice that had received OT-ITg cells 4 weeks earlier were infected with 200 CFU Mtb H37Rv via the aerosol route and treated weekly with either anti–IL-18 Ab or control IgG. Long-term survival (A), CFU in lung and spleen (B and C), a cytokine profile (F), as well as cell infiltrates (D and E) and iNOS expression in lung tissue (D) were assessed 27 days p.i. Results are presented as individual data points (B, C, and E), pooled data (mean ± SEM) (F), and representative images (D) of 12 (A) or 7 (B–F) mice per group from 2 pooled, independent experiments. *P < 0.05 and **P < 0.01 by log-rank (Mantel-Cox) test (A), unpaired, 2-tailed Student’s t test (B, C, and E), and 1-way ANOVA for each cytokine (F). Original magnification, ×50 (Giemsa), ×100 (TB-Fluor), ×200 (iNOS).