Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model depicting the mechanistic framework underlying mycobacterial growth control by noncognate sources of IFN-γ. Cytosolic translocation of ESAT-6 activates the NLRP3 inflammasome by a yet-to-be-defined mechanism within CD11c+ cells. Subsequent secretion of IL-18 drives the secretion of host-protective IFN-γ by Mtb-unrelated memory CD8+ T cells and NK cells.
