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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Ann Neurol. 2016 Apr 18;79(6):907–920. doi: 10.1002/ana.24641

Figure 3.

Figure 3

(A–C) Magnified from the locations denoted in Figure 2A, the maximum principal strain rate (MPSR) maps show that the corpus callosum (CC) endured the highest MPSR at bregma −1.0mm, where the diffuse axonal injury most likely occurred. (D–I) Correspondingly, the DTI tractography (D–F) and the phosphorylated neurofilament H (SMI31) neurofilament staining (G to I) also show that the most loss of white matter tracts and neurofilament staining were at bregma −1.0mm (arrow in H). Moderate injury signs are shown in the CC at bregma +1.0mm (arrow in G) and only few injuries were seen in the CC at bregma −3.0mm (I). (J) A strong negative correlation (r = −0.739, p = 0.002) is seen between the positive SMI31 staining and averaged MPSR. Scale bar = 400 μm.