Figure 4. Deficiency of Fbxo21 inhibits virus-induced activation of JNK/p38-AP-1 and IRF3.
(A–C) Fbxo21+/+ and Fbxo21-/- RAW264.7 cells (A, B) or L929 cells (C) were infected with VSV (MOI = 1) or HSV-1 (MOI = 5) as indicated. The phosphorylation of indicated molecules was examined by immunblot. (D, E) Fbxo21+/+ and Fbxo21-/- RAW264.7 cells (D) or L929 cells (E) were treated as in (A–C), and the nuclear proteins were extracted and examined for indicated transcription factors by immunoblot. One representative experiment of three was shown.