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. Author manuscript; available in PMC: 2016 May 31.
Published in final edited form as: Science. 2016 Mar 4;351(6277):1083–1087. doi: 10.1126/science.aad5497

Fig. 2. A MER41 element is essential for AIM2 inflammasome activation.

Fig. 2

A) Genome browser view of AIM2. ChIP-Seq tracks are normalized per million reads. The “Uniqueness” track displays genome-wide short-read alignability. B) qPCR of AIM2 levels in wild-type and ΔMER41.AIM2 HeLa cells after 24 hrs IFNG treatment. C) Western blot of AIM2 in wild-type and ΔMER41.AIM2 cells after IFNG treatment. D) Luciferase reporter assays of MER41.AIM2, MER41.AIM2 with mutations in the predicted STAT1 sites, and primate orthologs of MER41.AIM2 (see Fig S7A). E) Western blot of caspase-1 from supernatants of wild-type and ΔMER41.AIM2 cells infected with vaccinia virus (18). * p < 0.05, Student's t-test.