Figure 4. GM fails to block glutamate-induced GHS depletion and does not directly scavenge intracellular ROS.
(A) GSH levels were detected at 9 h after exposure to glutamate (5 mM) and GM (25 μM) (n=5). (B) HT-22 cells were exposed to H2O2 (50 μM) and GM (25 μM) for 20 min. ROS levels were detected by H2DCF and fluorescence was measured by plate reader (n=8). All experiments were repeated three times and the results indicate the mean ± SEM. ***P < 0.001 compared with control (one-way ANOVA, Tukey’s test).