Table 2. Varicella disease severity by vaccination status for clinically-diagnosed varicella case-subjects aged ≥4 years in Philadelphia, Pennsylvania and Antelope Valley, California, 2009-2011 a.
| Varicella Vaccination status | Overall p value |
2- vs. 1-dose p value |
|||
|---|---|---|---|---|---|
| Unvaccinated (n=8) n (%) |
1-dose (n=40) n (%) |
2-dose (n=45) n (%) |
|||
| Rash severityb | 0.01 | 0.81 | |||
| Mild (<50 lesions) | 1 (12.5) | 26 (65.0) | 31 (68.9) | ||
| Moderate/severe (50–500 lesions) | 6 (75.0) | 13 (32.5) | 14 (31.1) | ||
| Severe (>500 lesions) | 1 (12.5) | 1 (2.5) | 0 (0.0) | ||
| Fever | 0.36 | 0.11 | |||
| Yes | 2 (25.0) | 16 (41.0) | 11 (24.4) | ||
| No | 6 (75.0) | 23 (59.0) | 34 (75.6) | ||
| Most lesions are vesicular | <0.001 | 0.01 | |||
| Yes | 3 (60.0) | 9 (23.1) | 2 (4.5) | ||
| No | 2 (40.0) | 30 (76.9) | 42 (95.5) | ||
| Days of fever: median (IQR) | 2 (0–3) | 1.5 (1–2.5) | 2 (1–2) | 0.86 | 0.57 |
| Rash duration | 0.01 | 0.01 | |||
| <1 week (<7 days) | 2 (25.0) | 10 (25.6) | 24 (53.3) | ||
| ≥1 week (≥7 days) | 6 (75.0) | 29 (74.4) | 21 (46.7) | ||
| School missed | 0.17 | 0.89 | |||
| ≤1 school week (≤5 days) | 2 (33.3) | 3 (8.6) | 3 (7.7) | ||
| >1 school week (>5 days) | 4 (66.7) | 32 (91.4) | 36 (92.3) | ||
IQR: interquartile range
a
Missing and unknown responses excluded. Valid percentages presented.
b
Rash severity was defined as follows: 1) <50 or the total number of spots could be counted in 30 seconds; 2) 50–249 or you could place the child's hand between the spots without touching a spot; 3) 250–500 or you could NOT place a child's hand between the spots without touching a spot; or 4) >500 spots or the spots were so close you could hardly see normal skin.