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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2016 Apr 2;43(3):259–274. doi: 10.1007/s10928-016-9470-4

Table 4.

Estimated individual-level (mixed effects) structural parameters αi and βi on original scale. Units are the same as in Table 2. The parameters in the Weibull, gamma, and lognormal models have different meanings and are neither related nor comparable. Subscript i indicates individual parameter.

Model Parameter Subject Mean CV
(%)
2 3 4 5 6 7 8 9
Weibull αi 8.07 4.99 5.33 5.38 6.62 2.86 6.41 4.99 5.58 27.24
βi 135.87 128.11 123.96 125.17 132.51 109.37 130.34 119.70 125.63 6.61

Gamma αi 46.38 21.01 21.99 22.79 33.92 7.83 31.51 19.28 25.59 45.13
βi 2.77 5.65 5.23 5.10 3.67 12.72 3.87 5.75 5.59 54.83

Lognormal αi 4.84 4.76 4.72 4.74 4.81 4.56 4.79 4.68 4.74 1.87
βi 0.023 0.042 0.045 0.042 0.029 0.113 0.032 0.052 0.047 59.42