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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2016 Apr 2;43(3):259–274. doi: 10.1007/s10928-016-9470-4

Table 5.

Individual-level (mixed effects) estimates of derived RBC survival parameters, μi mean full lifespan; σi standard deviation of the full lifespan; τ95i : 95th percentile of the full lifespan distribution; μci mean current age; T50i residual half-life. All the units are in days. Subscript i indicates individual parameter.

Model Derived
Parameter		 Subject Mean
(days)		 CV
(%)
2 3 4 5 6 7 8 9
Weibull μi 128.01 117.61 114.23 115.42 123.58 97.47 121.36 109.89 115.95 8.10
σi 18.84 26.99 24.68 24.72 21.87 36.97 22.12 25.21 25.18 21.41
τ95i 155.65 159.64 152.30 153.48 156.40 160.51 154.67 149.15 155.22 1.41
μci 65.39 61.91 59.78 60.35 63.73 55.7 62.69 57.84 60.93 5.18
T50i 64.02 59.01 57.26 57.85 61.84 50.08 60.74 55.14 58.24 7.41
Gamma μi 128.42 118.69 114.98 116.23 124.33 99.63 122.02 110.77 116.88 7.63
σi 18.86 25.90 24.52 24.35 21.37 35.59 21.72 25.25 24.70 20.22
τ95i 160.93 164.24 158.05 158.96 161.40 164.48 159.83 155.27 160.39 1.93
μci 65.59 62.17 60.10 60.66 64.0 56.18 62.94 58.26 61.24 5.03
T50i 64.21 59.36 57.50 58.12 62.17 50.29 61.01 55.41 58.51 7.34
Lognormal μi 128.37 119.30 115.14 116.46 124.47 100.95 122.09 110.97 117.22 7.31
σi 19.51 24.69 24.61 24.20 21.36 34.98 22.04 25.55 24.62 18.81
τ95i 162.87 163.78 159.38 160.01 162.43 165.72 161.12 157.14 161.56 1.68
μci 63.50 58.56 56.47 57.16 61.41 48.62 60.17 54.29 57.52 8.04
T50i 64.19 59.66 57.58 58.23 62.24 50.65 61.05 55.49 58.64 7.36