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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2016 Mar 25;40:98–105. doi: 10.1016/j.ceb.2016.03.006

Figure 3. Force transduction to the nucleus and back.

Figure 3

Schematic demonstrating the flow of cellular force from the plasma membrane to the nucleus. Force is manifested as distortion of the plasma membrane or proteins within it. Tension is transmitted to the different systems of the cytoskeleton and transmitted to the nucleus via the LINC complex. In turn, the LINC complex transmits force across the nuclear membrane to the nuclear lamina and to chromatin. The nucleus rapidly responds to force application at the nuclear lamina and this response is conveyed back through these same elements.