Table 4.
Cumulative accuracy of the four most studied markers for the detection of PJI
| Marker | Studies | Total number | Sensitivity* | Specificity* | PPV | NPV | Accuracy |
|---|---|---|---|---|---|---|---|
| CRP | 5,6,13,15,16, 18,20,21 | 655 | 0.78 (0.72–0.83) | 0.95 (0.93–0.97) | 0.89 | 0.89 | 0.89 |
| IL-6 | 4,6,9–12,19 | 513 | 0.87 (0.81–0.92) | 0.89 (0.86–0.92) | 0.8 | 0.94 | 0.89 |
| α-defensin | 1,5,6 | 305 | 0.92 (0.85–0.97) | 0.99 (0.93–1.00) | 0.99 | 0.91 | 0.95 |
| IL-1β | 4,6,9,12 | 259 | 0.81 (0.70–0.89) | 0.93 (0.88–0.96) | 0.83 | 0.92 | 0.89 |
* Ninety-five confidence intervals in parentheses; PJI = periprosthetic joint infection; PPV = positive predictive value; NPV = negative predictive value; CRP = C-reactive protein; IL = interleukin.