Table 1.

Factors That Promote Lipotoxicity in Patients With NAFLD

Factor		Mechanism
Preventable	Iron overload	Oxidant stress
	Environmental toxins	Oxidant stress
	Medications	Oxidant stress
	Viral hepatitis	ER stress, oxidant stress, metabolic stress
Non-preventable	Congenital Liver Disease
	Alpha 1 antitrypsin deficiency	ER stress
	Wilson’s disease	Oxidant stress