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. Author manuscript; available in PMC: 2017 Jun 15.
Published in final edited form as: Biochem Pharmacol. 2016 Apr 22;110-111:117–129. doi: 10.1016/j.bcp.2016.04.012

Figure 6. Effects of αNF on FICZ-mediated CYP1A transcription and role of Ahr2.

Figure 6

Groups of 1-dpf embryos were exposed to αNF (0.1 to 2.5μ M) A) alone or B) in combination with FICZ (10nM). C) Embryos injected with Ahr2-MO were exposed to 0.5 μM αNF (A0.5), 10 nM FICZ (F10) or the combination of αNF and FICZ. All data were normalized to il13 as housekeeping gene and calibrated to DMSO-exposed non-injected embryos at respective time-point. Results in A-B) are from one experiment (n=3) and statistical differences among groups were determined by One-way ANOVA followed by Dunnett’s test. Results in C) is from a one experiment (n=3) and statistical differences between non-injected and Ahr2-MO injected groups at the same exposure were determined by student’s t test. Statistically significant differences are indicated by asterisks (*p<0.05, ** p<0.01 and *** p<0.001).