Table 1. Baseline characteristics of REGARDS participants with diabetes by the use of Calcium Chanel Blockers (CCB), n = 4978.
Characteristics | Non-users, n = 3494 | CCB users, n = 1484 | Verapamil users, n = 174 | ||
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n (%) | n (%) | P | n (%) | P | |
Socio-demographics | |||||
Age, mean years, SD | 64.9 ± 8.8 | 66.2 ± 8.5 | <0.001 | 66.1 ± 8.7 | 0.09 |
African American | 1795 (51.4) | 1007 (67.9) | <0.001 | 121 (69.5) | <0.001 |
Female | 1771 (50.7) | 840 (56.6) | <0.001 | 109 (62.6) | 0.002 |
Geographical region | 0.70 | 0.45 | |||
Stroke belt | 1256 (35.9) | 515 (34.7) | 70 (40.2) | ||
Stroke buckle | 811 (23.2) | 352 (23.7) | 35 (20.1) | ||
Non-belt | 1427 (40.8) | 617 (41.6) | 69 (39.7) | ||
Did not graduate from high school | 605 (17.3) | 324 (21.9) | <0.001 | 40 (23.0) | 0.001 |
Income < $35,000 | 1743 (49.9) | 830 (55.9) | <0.001 | 108 (62.1) | 0.06 |
Behaviors | |||||
Current smoking | 490 (14.1) | 198 (13.4) | 0.83 | 22 (12.6) | 0.62 |
Any alcohol use | 909 (26.8) | 344(23.6) | 0.03 | 41(24.0) | 0.37 |
Not physically active | 1354 (39.3) | 645 (44.2) | <0.001 | 74 (43.3) | 0.30 |
Medication non-adherence | 1034 (31.0) | 459 (31.7) | 0.66 | 56 (32.7) | 0.67 |
Other medical conditions | |||||
CHD | 868 (24.8) | 439 (29.6) | <0.001 | 42 (24.1) | 0.83 |
Other CVD | 418 (12.0) | 233 (15.7) | <0.001 | 16 (9.2) | 0.27 |
Hypertension | 2466 (70.7) | 1409 (95.0) | <0.001 | 168 (96.6) | <0.001 |
Physiological | |||||
Waist circumference, cm, mean, SD | 104.5 ± 15.4 | 105.8 ± 15.9 | <0.001 | 106.6 ± 15.7 | 0.08 |
Systolic blood pressure, mmHg, mean, SD | 130.7 ± 16.9 | 134.3 ± 17.3 | <0.001 | 139.3 ± 18.2 | <0.001 |
Total cholesterol mg/dL, mean, SD | 183.2 ± 42.6 | 178.1 ± 40.8 | <0.001 | 182.8 ± 43.6 | 0.91 |
HDL-C, mg/dl, mean, SD | 46.3 ± 14.0 | 48.0 ± 14.3 | <0.001 | 49.5 ± 16.0 | 0.004 |
Albumin to creatinine ratio, median, IQR | 11.0 [5.8–30.4] | 16.7 [7.5–70.8] | <0.001 | 17.9 [6.6–70.8] | <0.001 |
Heart Rate, beat/min, mean, SD | 71.1 ± 33.8 | 69.6 ± 12.4 | 0.02 | 69.4 ± 11.2 | 0.10 |
Diabetes management | |||||
Any anti-diabetic medication or insulin use | 2569 (73.5) | 1188 (80.1) | <0.001 | 145 (83.3) | 0.004 |
Abbreviations: CCB—calcium channel blocker, CHD—coronary heart disease, CVD—cardiovascular disease, IQR—interquartile range, HDL-C—high density lipoprotein cholesterol, SD—standard deviation.