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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2016 Mar 26;40:124–130. doi: 10.1016/j.ceb.2016.03.004

Figure 3. Model for systemic inflammation induced by age-related lamin-B reduction.

Figure 3

Old fat bodies exhibit loss of LAM, which then increases the expression of inflammatory factor (PGRPs) secreted into the circulation. These factors then block the local immune response of the gut and lead to over-proliferation and hyperplasia of this tissue.