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Effects of rhEndostatin on bone resorbing function of osteoclasts of BMMs cells induced by M-CSF and RANKL. (A) BMMs were seeded on dentine slices and treated with vehicle or rhEndostatin (12.5, 25, and 50 mM) for 3 h, then stimulated with M-CSF and RANKL. After culture for 5 days, the cells were removed from dentine slices, and the slices were stained with toluidine blue. (B) The total area of resorption pits was measured. ∗∗P < 0.01 compared with the vehicle-treated control.
