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Effects of rhEndostatin on the expression of osteoclast-specific markers. BMMs were treated with vehicle or rhEndostatin (12.5, 25, and 50 mM) for 3 h, then stimulated with M-CSF and RANKL. After culture for 5 days, total RNA was extracted. Quantitative real-time qPCR was used to analyze the level of mRNA expression of the indicated genes. GAPDH was used as a loading control. ∗∗P < 0.01 compared with the vehicle-treated control.
