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Simplified overview of the multiple interacting pathways leading to the pathogenesis of diabetic retinopathy. Key: PLA2, phospholipase A2; AA, arachidonic acid; COX2, cyclooxygenase 2; PGE2, prostaglandin E2; AGE, advanced glycation end-products; PKC, protein kinase C; VEGF, vascular endothelial growth factor; RAS, renin angiotensin system.
