Figure 5.

D2-mediated responses after the cue. A, Raster plots and histograms of firing rate from a single cue-responsive MSN during the ICSS task. Traces are aligned to cue onset (time 0). CTRL, Without iontophoresed drug; Q, in the presence of iontophoresed Q; RAC, in the presence of iontophoresed RAC. B, Summary histogram of all D2R cue-responsive cells (n = 23). C, Drug effects on task baseline and cue response firing on D2 cue cells. ***p < 0.001 for task baseline RAC compared task baseline CTRL and /+++p < 0.001 cue response CTRL compared with/task CTRL. D, Effects on cue-evoked and electrically evoked dopamine release after LP during ICSS (cue, ns; LP response, *p < 0.05).