Figure 3.
STN DBS stimulation site-dependent dopamine (DA) response projection map. A–F, To show the volume of DA released in caudate and putamen evoked by each stimulation contact, we overlaid an evoked-DA response volume projection color map (bilinear interpolation) from the caudate (A–C) and the putamen (D–F) onto the 3-D STN DBS contact location model in views representing neurologic convention. Coronal view (A), sagittal view (B), and axial view (C) of STN stimulation-dependent differences in caudate DA release (n = 51, stimulation sessions). Coronal view (D), sagittal view (E), and axial view (F) of STN stimulation-dependent differences in putamen DA release (n = 51, stimulation sessions). DA release in both caudate and putamen was increased when the location of stimulation was just outside the dorsolateral posterior border of the STN, a location that would contain the nigrostriatal fibers that run just dorsal to the STN.