Table 1.
Baseline characteristics of patients
| Characteristics | Metformin N=7728 |
Sulfonylurea N=4425 |
Metformin + Sulfonylurea N=1000 |
|---|---|---|---|
| Age, years median (IQR)* | 59 (54, 67) | 60 (54, 71) | 58 (53,65) |
| Male % | 95 | 97 | 96 |
| Race, % | |||
| White | 77 | 77 | 69 |
| Black | 12 | 17 | 19 |
| Other/Unknown | 11 | 8 | 13 |
| Estimated glomerular filtration rate (eGFR) ml/min, median (IQR) | 81 (72, 93) | 80 (71, 93) | 82 (73, 97) |
| Creatinine (mg/dL), median (IQR) | 1.0 (0.9, 1.1) | 1.0 (0.9, 1.1) | 1.0 (0.9, 1.1) |
| Urine protein measure available at baseline, % | 64 | 67 | 68 |
| Proteinuria, % | 13 | 17 | 17 |
| Systolic blood pressure (mmHg), median (IQR) | 134 (124, 145) | 137 (126, 149) | 137(125,148) |
| Diastolic blood pressure (mmHg), median (IQR) | 78 (70, 84) | 78 (70, 85) | 77 (70, 85) |
| History of hypertension, % | 74 | 70 | 68 |
| History of Cardiovascular disease, % | 219 | 23 | 17 |
| HbA1c, median (IQR) | 7.1 (6.5, 7.9) | 7.3 [6.6,8.4] | 7.9 (6.8,10) |
| Body mass index (kg/m2), median (IQR) | 32 (29, 36) | 30 (27, 34) | 31(28, 36) |
| Baseline use of medications | |||
| ACEI or ARBs, % † | 53 | 50 | 52 |
| Diuretics, % | 41 | 37 | 31 |
| Statins, % | 54 | 45 | 42 |
| Number of outpatient medications, median (IQR) | 5 (2, 8) | 4 (2, 7) | 2 (0, 5) |
| Number of outpatient visits, median (IQR) | 5 (3, 8) | 5 (3, 8) | 2 (0,5) |
| Marital status (% married) | 64 | 58 | 60 |
| Hospitalized % | 11 | 16 | 14 |
*
IQR interquartile range
†
ACEI angiotensin converting enzyme inhibitors, ARB angiotensin receptor blocker,