Figure 3.
AvrA modulates target genes of the STAT3 pathway in AOM/DSS colonic tumors. (A) mRNA expression of target genes of the STAT3 pathway in the AOM/DSS colon post–Salmonella infection. The total RNA from intestinal mucosa was extracted for a real-time PCR 45 weeks postinfection. Transcripts were assayed in triplicate. Data are means ± SD of n= 5 mice in each group. (B) The effect of AvrA on intestinal proliferation post–Salmonella infection. PCNA and p-c-Jun staining in colon 45 weeks postinfection.