Table 1.
Cytotoxicity of the LD sera or VER in combination with cisplatin or paclitaxel in SKOV3 and SKOV3/DDP cells in vitro.
| Drug and concentration | IC50 (mg·L−1) | Resistance fold | Reversal fold | |
|---|---|---|---|---|
| SKOV3 | SKOV3/DDP | |||
| Cisplatin | 3.58 ± 0.12 | 14.79 ± 0.41∗∗ | 4.13 | |
| Paclitaxel | 1.78 ± 0.31 | 6.86 ± 0.22∗∗ | 3.85 | |
| LD sera + cisplatin | 3.22 ± 0.08 | 4.39 ± 0.17∗∗ | 1.36 | 3.04 |
| LD sera + paclitaxel | 1.59 ± 0.27 | 2.33 ± 0.42∗∗ | 1.47 | 2.62 |
| VER + cisplatin | 3.34 ± 0.13 | 4.09 ± 0.29# | 1.22 | 3.39 |
| VER + paclitaxel | 1.69 ± 0.24 | 1.95 ± 0.30# | 1.18 | 3.26 |
LD, low-dose. VER, verapamil. ∗∗ P < 0.01 compared with each other, # P < 0.01 compared with each other.