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. 2016 May 18;2016:2954721. doi: 10.1155/2016/2954721

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Copyright © 2016 Rosa de Hoz et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Retinal macroglia in the mouse retina. Retinal whole-mount. Double immunostaining for GFAP (red) and MHC-II (green) after 15 days of laser-induced ocular hypertension. (A)–(C): naïve eyes; (D)–(F): contralateral eyes; (G)–(I): OHT eyes. In contralateral eyes, MHC-II immunoreaction of astrocytes (arrow) and Müller cells (arrowhead) in (E) was increased with respect to naïve eyes (arrow) in (B). In OHT eyes, MHC-II immunoreaction of Müller cells (arrowhead) in (H) was notably upregulated in comparison with contralateral (E). In OHT eyes the Müller cells were GFAP⁺ throughout the retina and appeared as punctate structures between the astrocytes and their radiating processes (G). Fluorescence microscopy and image acquisition using the ApoTome. GFAP: glial fibrillary acidic protein; MHC: major histocompatibility complex; OHT: ocular hypertension (from Figure 10 of [19] with permission).