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. 2016 May 18;2016:8121985. doi: 10.1155/2016/8121985

Table 4.

Selected genes expressed on melanoma cells which correlate with overall survival. The genes were depicted by Maxstat-package utilizing a Cox-regression analysis followed by rank statistics to determine the best cut-off value which separates patients into favorable versus unfavorable survival groups. ↑ = higher expression correlates with prolonged survival time; ↓ = higher expression correlates with decreased survival time.

Gene ↑/↓ Full name Maxstat cut point Maxstat p value CoxPH hazard ratio CoxPH p value
MICA MHC class I-related chain A (NKG2D ligand) 7.8 0.018 0.5 0.015
CTAG2 Cancer testis antigen 2 (LAGE-1, NY-ESO-2) 5.9 0.014 0.58 0.015
SSX4 /// SSX4B Synovial sarcoma, X breakpoint 4 3.9 0.008 0.58 0.017
TGFA Transforming growth factor α 4.08 0.011 0.66 0.018
KIR3DX1 Killer cell Ig-like receptor 4 0.023 0.56 0.02
MAGEA1 Melanoma antigen family A, 1 5.52 0.042 0.69 0.028
SSX1 Synovial sarcoma, X breakpoint 1 3.28 0.035 0.63 0.043
SMAD1 SMAD family member 1 5.5 0.046 2.58 0.0002
HSPH1 Heat shock 105 kDa/110 kDa protein 1 10.7 0.008 1.9 0.007