Table 4.
Selected genes expressed on melanoma cells which correlate with overall survival. The genes were depicted by Maxstat-package utilizing a Cox-regression analysis followed by rank statistics to determine the best cut-off value which separates patients into favorable versus unfavorable survival groups. ↑ = higher expression correlates with prolonged survival time; ↓ = higher expression correlates with decreased survival time.
| Gene | ↑/↓ | Full name | Maxstat cut point | Maxstat p value | CoxPH hazard ratio | CoxPH p value |
|---|---|---|---|---|---|---|
| MICA | ↑ | MHC class I-related chain A (NKG2D ligand) | 7.8 | 0.018 | 0.5 | 0.015 |
| CTAG2 | ↑ | Cancer testis antigen 2 (LAGE-1, NY-ESO-2) | 5.9 | 0.014 | 0.58 | 0.015 |
| SSX4 /// SSX4B | ↑ | Synovial sarcoma, X breakpoint 4 | 3.9 | 0.008 | 0.58 | 0.017 |
| TGFA | ↑ | Transforming growth factor α | 4.08 | 0.011 | 0.66 | 0.018 |
| KIR3DX1 | ↑ | Killer cell Ig-like receptor | 4 | 0.023 | 0.56 | 0.02 |
| MAGEA1 | ↑ | Melanoma antigen family A, 1 | 5.52 | 0.042 | 0.69 | 0.028 |
| SSX1 | ↑ | Synovial sarcoma, X breakpoint 1 | 3.28 | 0.035 | 0.63 | 0.043 |
| SMAD1 | ↓ | SMAD family member 1 | 5.5 | 0.046 | 2.58 | 0.0002 |
| HSPH1 | ↓ | Heat shock 105 kDa/110 kDa protein 1 | 10.7 | 0.008 | 1.9 | 0.007 |