Figure 4.

No change on BACE-1 protein expression level was observed in the brains of WT and APP/PS1 mice. Western blot showed comparable expression level of BACE-1 in the brain of WT and APP/PS1 mice at 3 months of age (a). Relative β-secretase activity in the brain of WT and APP/PS1 mice was expressed (3 months old) (b). Western blot showed comparable expression level of BACE-1 in the brain of WT and APP/PS1 mice at 6 months of age (c). Relative β-secretase activity in the brain of WT and APP/PS1 mice was expressed (6 months old) (d). Data are expressed as means ± SEM. n = 5, each group.