Table 2.
ECG basal parameters in conscious mice
| ECG parameter | WT | S2814D+/+ | PLNKO | SD+/+/KO |
|---|---|---|---|---|
| HR (beats min−1) | 598.0 ± 52.2 | 663.9 ± 14.7 | 543.5 ± 36.0† | 649.9 ± 16.2 |
| RR (ms) | 111.4 ± 7.2 | 90.9 ± 2.6* | 107.8 ± 10.1 | 90.4 ± 2.0* |
| PR (ms) | 35.8 ± 1.2 | 35.4 ± 1.0 | 36.5 ± 1.2 | 32.9 ± 0.8 |
| P (ms) | 14.1 ± 2.0 | 11.2 ± 0.5 | 10.9 ± 0.8 | 11.0 ± 0.5 |
| QRS (ms) | 11.7 ± 0.8 | 11.0 ± 0.3 | 13.8 ± 0.7 | 11.5 ± 0.8 |
| QT (ms) | 47.1 ± 1.1 | 45.9 ± 1.3 | 70.0 ± 8.6*,† | 53.1 ± 2.4‡ |
| QTc (ms) | 44.9 ± 1.8 | 48.1 ± 1.3 | 67.0 ± 4.9*,† | 55.7 ± 2.1‡ |
HR, heart rate; RR, RR period duration; PR, PR interval duration; P, P wave duration; QRS, QRS complex duration; QT, QT interval duration; QTc, corrected QT. Of note, SD+/+/KO mice showed a prolongation of the QT interval, similar to that observed in PLNKO mice. Although we did not explore the cause of this prolongation, it may result from the down‐regulation of outward K+ currents that has been described in the presence of similar chronic alteration of intracellular Ca2+ homeostasis, in mice overexpressing SERCA2a (Xu et al. 2005). *P < 0.05 vs. WT, † P < 0.05 vs. S2814D+/+, ‡ P < 0.05 vs. PLNKO (n = 4–11 for the different groups).