Table 1.
Body weight (BW), body temperature (T b) and baseline ventilatory variables in P16 rats after 5 days of SH exposure (P11–15); mortality was determined from the number of rats that had survived through to weaning (P28)
| Variable | |||||||
|---|---|---|---|---|---|---|---|
| Treatment | BW (g) | T b (°C) | V E (ml g−1 min−1) | V T (ml g−1) | f B (breaths min–1) | Mortality (%) | |
| Normoxia | Saline (n = 12) | 35.2 ± 3.1 | 36.9 ± 0.4 | 1.06 ± 0.23 | 0.0077 ± 0.0013 | 137.8 ± 12.9 | 0 |
| Minocycline (n = 8) | 30.8 ± 1.6* | 36.9 ± 0.3 | 1.04 ± 0.16 | 0.0078 ± 0.0009 | 132.6 ± 12.7 | 0 | |
| SH | Saline (n = 12) | 22.6 ± 4.9* | 36.5 ± 0.9 | 1.51 ± 0.46* | 0.0113 ± 0.0019* | 132.8 ± 27.8 | 50 |
| Minocycline (n = 15) | 24.1 ± 5.0* | 37.1 ± 0.4 | 1.47 ± 0.39* | 0.0109 ± 0.0025* | 137.4 ± 24.6 | 12 | |
Values are mean ± 1SD.
*Significant difference from normoxia saline‐treated rats (P < 0.05).