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. 2016 Feb 4;594(11):3061–3077. doi: 10.1113/JP271332

Figure 9. Sex‐dependence of cardiac TPCs levels and autophagy markers in cardiac surgery patients .

Figure 9

TPC1 and TPC2 transcripts are increased in women vs. men (A: women: n = 100; men: n = 199) hearts. Western blot confirmed increases of TPCs protein levels (B: women: n = 11; men: n = 11) in women hearts. C, human cardiac protein levels of LC3I (women: n = 14; men: n = 16), LC3II (women: n = 14; men: n = 16) and p62 (women: n = 10, men: n = 9), but not the LC3II/LC3I ratio (women: n = 14, men: n = 16), are lower in women than in men. D, negative correlation between p62 and TPCs transcripts in human hearts (n = 15). E, absence of a significant influence of sex in the cardiac protein levels of the Rab GTP‐ase Rab7 (women: n = 8; men: n = 8) and of the lysosomal associated membrane protein LAMP‐1 (women: n = 8; men: n = 8). Bar graphs show the mean ± SEM or median with interquartile range. The correlation coefficients were measured as the Spearman ρ. Statistical significance (Mann–Whitney U test): *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001. ρ, Spearman's rho.