Figure 1. Association of proteins with IP₃Rs .

Key functional domains of a single IP₃R subunit are shown: the suppressor domain (SD), IP₃‐binding core (IBC), cytosolic regulatory domain, transmembrane domains (TMDs) and the cytosolic C‐terminus (CT). The sites to which proteins are proposed to bind are shown. Many additional proteins are thought to associate with IP₃Rs, but the binding sites have not been identified. Abbreviations and references are provided in Tables 1, 2, 3, 4.