Table 2.
Proteins that form complexes with IP3Rs and inhibit their activity
| Protein | References |
|---|---|
| Proteins that bind reversibly and disrupt activation by IP3 and/or Ca2+ | |
| Ankyrin‐R (ANK1) | Bourguignon et al. 1993; Joseph & Samanta, 1993 |
| Bcl‐2 (B‐cell lymphoma 2)a | Chen et al. 2004; Monaco et al. 2012; Chang et al. 2014 |
| Ca2+‐binding protein 1 (CaBP1)b | Yang et al. 2002; Li et al. 2013 |
| Calmodulin (CaM) | Maeda et al. 1991; Yamada et al. 1995 |
| Carbonic anhydrase‐related protein (CARP; CA8) | Hirota et al. 2003 |
| Caspase‐3 | Hirota et al. 1999 |
| CIB1 (Ca2+ and integrin‐binding protein 1; calmyrin)b | White et al. 2006 |
| DANGER (IP3R‐interacting protein) | van Rossum et al. 2006 |
| ERp44 (endoplasmic reticulum resident protein 44) | Higo et al. 2005 |
| FKBP1A (FK506‐binding protein 1A; FKBP12) | Cameron et al. 1995 b |
| GIT1/GIT2 (ARF GTPase‐activating protein 1/2) | Zhang et al. 2009 |
| IRBIT (IP3‐binding protein released with IP3) | Ando et al. 2003 |
| K‐Ras | Sung et al. 2013 |
| MRVI1 (IRAG; IP3R‐associated cGMP kinase substrate) | Schlossman et al. 2000 |
| Nuclear protein localization protein 4 homologue (NPL4) | Alzayady et al. 2005 |
| Polycystin‐1 (PC1; TRPP1) | Li et al. 2005 |
| Proteins that post‐translationally modify IP3Rs | |
| AKT1 (RAC‐α serine/threonine protein kinase; PKB) | Khan et al. 2006; Szado et al. 2008 |
| Ca2+/calmodulin‐dependent protein kinase II (CaMKII) | Ferris et al. 1991; Bare et al. 2005 |
| Calpain | Μagnusson et al. 1993; Wojcikiewicz & Oberdorf, 1996 |
| E3 ubiquitin ligase AMFR (GP78)c | Pearce et al. 2007 |
| E3 ubiquitin ligase RNF170c | Lu et al. 2011 |
| Erlin‐1/Erlin‐2 (SPFH domain‐containing protein 1/2)c | Pearce et al. 2007; Pearce et al. 2009 |
| MAPK1/MAPK3 (mitogen‐activated protein kinase 1/3) | Bai et al. 2006 |
| Protein phosphatase 1A (PP1A) | Tang et al. 2003 a; Chang et al. 2014 |
| Transglutaminase‐2 (TGM2) | Hamada et al. 2014 |
| Transitional endoplasmic reticulum ATPase (p97)c | Alzayady et al. 2005 |
| Ubiquitinc | Bokkala & Joseph, 1997; Oberdorf et al. 1999 |
| Ubiquitin‐conjugating enzyme E2 7 (UBC7)c | Webster et al. 2003 |
| Ubiquitin conjugation factor E4A (UFD2)c | Alzayady et al. 2005 |
| Ubiquitin fusion degradation 1 protein (UFD1)c | Alzayady et al. 2005 |