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Nse-BMP4;MOR−/− double mutant mice form significantly less HO. Whole body X-ray imaging reveals a dramatic difference in the efficacy of HO formation between Nse-BMP4;MOR+/− (a–d) and Nse-BMP4;MOR−/− mice (e–j) after similar injuries. k Quantification of the wet weight of lesional tissues of (a–j). *P < 0.05 vs. control
