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. 2016 Apr 6;11(6):2590–2596. doi: 10.3892/etm.2016.3231

Figure 4.

Figure 4.

Effects of H2 and/or hyperoxia on the activity of serum antioxidant enzyme as well as the levels of serum oxidative product and inflammatory cytokines in zymosan-challenged mice. (A) SOD activity and serum levels of (B) 8-iso-PGF2α, (C) TNF-α and (D) HMGB1 level. The mice were treated with or without 2% H2 and/or 98% O2 inhalation for 3 h starting at 1 and 6 h after NS or zymosan injection, respectively. The serum was harvested for measuring these indicators at 24 h after NS or zymosan injection. Values are expressed as the mean ± standard error of the mean (n=6 per group). *P<0.05 vs. NS group; †P<0.05 vs. ZY group; ‡P<0.05 vs. ZY + H2 group; §P<0.05 vs. ZY + O2 group. SOD, superoxide dismutase; 8-iso-PGF2α, 8-iso-prostaglandin F2α; HMGB1, high-mobility group box 1 protein; NS, normal saline; ZY, zymosan.