Table 2. Areas of significant volume difference in PD patients with probable RBD (pRBD) compared to PD patients without (noRBD).

Area	Xa	Ya	Za	T-scoreb	P-valuec
pRBD < noRBD
Pontomesencephalic Tegmentum
Left	−4	−28	−22	−3.70	0.00011
Right	4	−30	−20	−2.72	0.00312
Base of the Pons
Left	−5	−18	−36	−3.50	0.00029
Right	4	−18	−34	−2.72	0.00291
Medullary Reticular Formation
Left	−4	−42	−62	−2.71	0.00364
Cerebellum – Deep Nuclei
Left	−24	−46	−34	−3.60	0.00022
Right	24	−46	−34	−3.90	0.00006
Cerebral Peduncle
Left	−12	−18	−20	−2.72	0.00376
Right	12	−16	−18	−2.33	0.01107
Hypothalamus
Left	−4	−4	−10	−3.31	0.00056
Right	4	−6	−10	−4.29	0.00001
Thalamus
Left	−19	−18	16	−3.31	0.00059
Right	12	−20	0	−3.50	0.00025
Putamen
Left	−24	10	−10	−4.19	0.00002
Right	32	−6	−6	−3.31	0.00062
Claustrum
Left	−29	12	−8	−3.50	0.00025
Right	32	10	−8	−3.99	0.00004
Internal Capsule – Posterior lobe
Left	−22	−12	10	−3.11	0.00125
Right	24	−18	10	−2.91	0.00210
Amygdala
Left	−26	−8	−12	−3.50	0.00023
Right	30	−8	−8	−3.21	0.00069
Lingual Gyrus
Left	−22	−68	−15	−3.21	0.00084
Right	32	−70	−10	−2.91	0.00150
Supramarginal Gyrus
Left	−56	−32	32	−3.21	0.00090
Anterior cingulate
Right	14	50	−12	−3.21	0.00077
Superior Longitudinal Fasciculus
Left	−22	−12	32	−3.51	0.00025
Right	22	8	32	−3.50	0.00034
Inferior Longitudinal Fasciculus
Left	−36	−4	−24	−3.99	0.00004
Right	34	2	−20	−3.90	0.00006
pRBD > noRBD
Olfactory Trigone
Left	−6	18	−23	2.58	0.00451
Right	6	12	−18	3.66	0.00019
Rectal Gyrus/Orbitofrontal Gyrus
Right	10	36	−14	3.96	0.00003
Medial Prefrontal Cortex
Left	−4	54	36	3.27	0.00064
Right	6	54	38	4.25	0.00001
Superior Frontal Gyrus
Left	−6	14	50	2.98	0.00165
Right	5	20	58	3.86	0.00008
Inferior Frontal Gyrus
Left	−51	16	16	3.37	0.00039
Right	56	26	16	3.76	0.00009
Mid-Cingulate Gyrus
Left	−16	−24	40	3.76	0.00009
Right	12	−18	40	4.06	0.00003
Superior Temporal Gyrus
Left	−64	−48	20	4.16	0.00002
Right	69	−42	16	4.65	0.00000

^aBased on Montreal Neurological Institute 152 brain imaging template; ^bPeak voxel T-score; ^cPeak voxel P-value.