Table I.
Association between growth retardation and each of the demographic, transfusion, chelation characteristics, compliance and serum ferritin level.
| Growth retardation (n=100) | |||||
|---|---|---|---|---|---|
| Characteristics | Patients, n | Negative (n=30), n (%) | Positive (n=70), n (%) | χ2 test | P-value |
| Age, years | 5.74 | 0.016a | |||
| ≤14 | 66 | 25 (37.9) | 41 (62.1) | ||
| >14 | 34 | 5 (14.7) | 29 (74.3) | ||
| Gender | 0.01 | 0.9 | |||
| Male | 54 | 16 (29.6) | 38 (70.4) | ||
| Female | 46 | 14 (30.4) | 32 (69.6) | ||
| Age of start transfusion, months | 11.98 | <0.001b | |||
| ≤9 | 68 | 13 (19.1) | 55 (80.9) | ||
| >9 | 32 | 17 (53.1) | 15 (46.9) | ||
| Frequency of transfusion, weeks | 15.39 | <0.001b | |||
| Every 2–3 | 43 | 4 (9.3) | 39 (90.7) | ||
| Every 4–5 | 57 | 26 (45.6) | 31 (54.5) | ||
| Age of start chelation, years | 28.70 | <0.001b | |||
| ≤3 | 73 | 11 (15.1) | 62 (84.9) | ||
| >3 | 27 | 19 (70.4) | 8 (29.6) | ||
| Type of chelators | 7.59 | 0.055 | |||
| DFX | 19 | 9 (47.4) | 10 (52.6) | ||
| DFP | 40 | 11 (27.5) | 29 (72.5) | ||
| DFO | 31 | 5 (16.1) | 26 (83.9) | ||
| DFO+DFP | 10 | 5 (50.0) | 5 (50.0) | ||
| Compliance, % | 9.90 | 0.0015a | |||
| <60 | 69 | 14 (20.3) | 55 (79.7) | ||
| ≥60 | 31 | 16 (51.6) | 15 (48.4) | ||
| Mean serum ferritin level ± SD (range), ng/ml | 2,227.8±796.1 (836–5,000) | 4,155.9±1,841.3 (1,026–8,500) | 5.50 | <0.001b | |
a
P<0.05
b
P<0.001. DFX, deferasirox; DFP, deferiprone; DFO, desferrioxamine; SD, standard deviation.