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. 2016 Apr 4;4(6):728–736. doi: 10.3892/br.2016.646

Table II.

Association between hypogonadism and each of the demographic, transfusion, chelation characteristics, compliance and serum ferritin level.

Hypogonadism (n=100)

Characteristics Patients, n Negative (n=33), n (%) Positive (n=67), n (%) χ2 test P-value
Age, years   5.49 0.019a
  ≤14 66 27 (40.9) 39 (59.1)
  >14 34   6 (17.6) 28 (82.4)
Gender   0.01 0.93
  Male 54 18 (33.3) 36 (66.7)
  Female 46 15 (32.6) 31 (67.4)
Age of start transfusion, months 14.81 <0.001b
  ≤9 68 14 (20.6) 54 (79.4)
  >9 32 19 (59.4) 13 (40.6)
Frequency of transfusion, weeks 19.16 <0.001b
  Every 2–3 43 4 (9.3) 39 (90.7)
  Every 4–5 57 29 (50.9) 28 (49.1)
Age of start chelation, years 28.20 <0.001b
  ≤3 73 13 (17.8) 60 (82.2)
  >3 27 20 (74.1)   7 (25.9)
Type of chelators   5.70 0.12
  DFX 19   9 (47.4) 10 (52.6)
  DFP 40 13 (32.5) 27 (67.5)
  DFO 31   6 (19.4) 25 (80.6)
  DFO+DFP 10   5 (50.0)   5 (50.0)
Compliance, %   9.69 0.0018a
  <60 69 16 (23.2) 53 (76.8)
  ≥60 31 17 (54.8) 14 (45.2)
Mean serum ferritin level ± SD (range), ng/ml 2,207.2±755.9 (836–5,000) 4,252.4±1,824.1 (1,626–8,500)   6.12 <0.001b
a

P<0.05

b

P<0.001. DFX, deferasirox; DFP, deferiprone; DFO, desferrioxamine; SD, standard deviation.