Table VI.
Association between patient genotype and endocrinal complications.
| Characteristics | Patients, n (n=100) | β0β0 (n=34), n (%) | β+β0 (n=6), n (%) | β+β+ (n=60), n (%) | χ2 test | P-value |
|---|---|---|---|---|---|---|
| Gender | 3.71 | 0.15 | ||||
| Male | 54 | 14 (25.9) | 3 (5.6) | 37 (68.5) | ||
| Female | 46 | 20 (43.5) | 3 (6.5) | 23 (50.0) | ||
| Age of start transfusion, months | 18.60 | <0.001a | ||||
| ≤9 | 68 | 32 (47.1) | 5 (7.4) | 31 (45.6) | ||
| >9 | 32 | 2 (6.3) | 1 (3.1) | 29 (90.6) | ||
| Frequency, weeks | 79.20 | <0.001a | ||||
| Every 2 | 34 | 29 (85.3) | 2 (5.9) | 3 (8.8) | ||
| Every 3 | 9 | 2 (22.2) | 3 (33.3) | 4 (44.4) | ||
| Every 4 | 49 | 2 (4.1) | 1 (2.0) | 46 (93.9) | ||
| Every 5 | 8 | 1 (12.5) | 0 (0.0) | 7 (87.5) | ||
| Age of start chelation, years | 13.05 | <0.001a | ||||
| ≤3 | 73 | 31 (42.5) | 6 (8.2) | 36 (49.3) | ||
| >3 | 27 | 3 (11.1) | 0 (0.0) | 24 (88.9) | ||
| Growth retardation | 16.35 | <0.001a | ||||
| Negative | 30 | 2 (6.7) | 1 (3.3) | 27 (90.0) | ||
| Positive | 70 | 32 (45.7) | 5 (7.1) | 33 (47.1) | ||
| Hypogonadism | 16.09 | <0.001a | ||||
| Negative | 33 | 3 (9.1) | 1 (3.0) | 29 (87.9) | ||
| Positive | 67 | 31 (46.3) | 5 (7.5) | 31 (46.3) | ||
| Hypothyrodism | 14.75 | <0.001a | ||||
| Negative | 92 | 28 (30.4) | 4 (4.3) | 60 (65.2) | ||
| Positive | 8 | 6 (75.0) | 2 (25.0) | 0 (0.0) | ||
| Hypoparathyroidism | 6.58 | 0.037b | ||||
| Negative | 93 | 29 (31.2) | 5 (5.4) | 59 (63.4) | ||
| Positive | 7 | 5 (71.4) | 1 (14.3) | 1 (14.3) | ||
| Diabetes mellitus | 0.79 | 0.67 | ||||
| Negative | 92 | 31 (33.7) | 5 (5.4) | 56 (60.9) | ||
| Positive | 8 | 3 (37.5) | 1 (12.5) | 4 (50.0) |
a
P<0.001
b
P<0.05.