Figure 2. Evaluation of macrophage infiltration in lungs of C57BL/6 mice in response to infection with S. pneumoniae TIGR4 and ∆potABCD.
Expression of F4/80 and CD11b double positive cells from lung homogenates of C57BL/6 mice (n = 3) is shown. Data is expressed as percentage of F4/80, CD11b double positive cells compared to PBS at [A] 4 h and [B]12 h. Mice were challenged with 107 S. pneumoniae TIGR4, ∆potABCD or PBS. Each datum point represents results from one animal. Data are represented as mean ± SEM. One-way ANOVA and Tukey’s multiple testing comparison was used to calculate the statistical significance (***p-value = 0.0001; ****p-value = <0.0001).