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Deletion of TAK1 in DCs results in suppressed humoral and cellular immune response. WT and Map3k7 DC mice were immunized with SRBC as stated in the PFC assay section. (A) Counts of PFCs/106 splenocytes. (B) Serum hemolytic activity (HC 50). (C) The increase in foot pad increase. (D) Determination of serum IgM, IgG, and IgA. The bars represented mean ± SD (n = 9). ***P < 0.001 indicate significant changes compared to the WT group.
