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. 2016 Apr 7;4(6):746–750. doi: 10.3892/br.2016.647

Figure 1.

Figure 1.

Antibody titer of mice vaccinated with HPVL2 relative proteins. Animals were immunized with HPV16L2-N88, HPV16L2-N200, PTD-HPV16L2-N88, PTD-HPV16L2-N200 and PTD: HPV16L2-N88 (mol ratio, 1:1) and PDT: HPV16L2-N200 (mol ratio, 1:1), the effective amount of protein was 100 µg/100 µl/animal. Protein was mixed with Freunds complete adjuvant, and the animals were immunized at weeks 0, 2 and 4. One week after the completion of the immunization, the serum was collected for indirect ELISA. No significant difference was identified between the total antibody levels in HPV16L2-N88-related groups. In the HPV16L2-N200-related groups, the total antibody titers in the PTD-HPV16L2-N200 groups were higher than those of the HPV16L2-N200 groups (P<0.05) and PTD: HPV16L2-N200 groups (P<0.05). No significant difference was identified between the HPV16L2-N200 and PTD: HPV16L2-N200 groups. In all conditions, the total antibodies in HPV16L2-N200-related groups were higher than those in the HPV16L2-N88 groups. HPV, human papillomavirus; PTD, protein transduction domain; ELISA, enzyme-linked immunosorbent assay.