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. 2016 Jun 1;6:27059. doi: 10.1038/srep27059

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(A) Increase of abnormal karyotypes with passaging in I3, I4 and I20 lines. Light grey represents the percentage of normal karyotypes and dark grey the percentage of abnormal karyotypes. (B) Evolution of the main rearrangements observed in I3 and I20 lines. (C) Examples of the most represented abnormal karyotypes in I3, I4 and I20 lines at late passages. Arrows indicate the rearrangements. (D) Identification of common genomic duplication on chromosomes 3, 4 and 10 in both I3 and I4 lines by CGH analysis (green lines = duplications; red lines = deletions). (E) FISH analysis using painting probes SSC8 (green) and SSC4 (red) revealed the translocation of a duplicated fragment of chromosome 4 at the extremity of chromosome 8 with was not labeled by SSC8 probe (yellow arrow).